Therapeutic drug monitoring in epilepsy treatment
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چکیده
Drug monitoring as a means to adapt the dosage of antiepileptic drugs to achieve a particular concentration in blood is well documented. However, there are few studies showing the extent to which drug monitoring contributes toward greater effectiveness in epilepsy treatment as measured by better seizure control. The findings of SBU Alert show that there is currently poor* evidence to demonstrate the benefits of the method for patients.
منابع مشابه
CCL2 Polymorphism in Drug-Resistant and Drug-Responsive Patients with Epilepsy in Isfahan, Iran
ABSTRACT Background and objective: Approximately 50 million people worldwide (1% of the world's population) suffer from epilepsy. Among 700 thousand people with epilepsy in Iran, 20% have refractory epilepsy. Accumulation of leukocytes in patients' brain parenchyma is thought to be related to different types of epilepsy. Recent clinical observat...
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A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded to be a chronic brain disease.However, despite numerous drug treatments, approximately, 30–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice in which invol...
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BACKGROUND The aim of drug treatment for epilepsy is to prevent seizures without causing adverse effects. To achieve this, drug dosages need to be individualised. Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients. OBJECTIVES To review the evidence regarding the effects of therapeutic drug monitor...
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Epilepsy and seizures have been described and treatment has been attempted for at least 4000 years. There are early accounts describing treatment of seizures in ancient Persia, India, and China. Treatments have ranged from drinking a gladiator’s blood in first century Rome to the modern era of antiepileptic drugs (AEDs). Potassium bromide was first introduced as treatment for epilepsy in 1857. ...
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